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TitleAuthor(s)YearMagazineMethodCategoryFindingsFlourish 580?
Efficacy of oral 20-hydroxyecdysone (BIO101), a MAS receptor activator, in adults with severe COVID-19 (COVA): a randomized, placebo-controlled, phase 2/3 trialLobo et al.2024The Lancet20-hydroxyecdyson (BIO101)Clinical researchThe COVA study showed significant efficacy of BIO101 (43.8% reduction) with an NNT of 9, confirming its safety. These results endorse RAS modulation via MASR activation for the treatment of COVID-19 and call for further research.No
Anti-Adipogenic Activity of Rhaponticum carthamoides and Its Secondary MetabolitesTodorova et al.2023NutrientsRhaponticum carthamoides extract (RCE)Applied researchThe HPTLC method confirmed the presence of 20-hydroxyecdysone (20E), ponasterone A (PA) and turkesterone (TU) in RCE. In addition, evaluation of anti-adipogenic activity showed that RCE, 20E and TU significantly reduced fat accumulation in human adipocytes. Further experiments showed that RCE and 20E significantly stimulated basal lipolysis. The results obtained from RCE, 20E and TU are worthy of further mechanistic evaluation.No
Rhaponticum carthamoides improved energy metabolism and oxidative stress through the SIRT6/Nrf2 pathway to ameliorate myocardial injuryZheng et al.2022PhytomedicineRhaponticum carthamoides (Rha)Applied researchRha enhances NAD+/NADH, ATP, LD and antioxidant levels in myocardial injury in ISO-treated rats and H9c2 cells. Mechanistic studies show improvement in energy metabolism and oxidative stress, crucial for the protective effect of Rha on myocardial injury.No
The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated reviewDas et al.2021Acta Pharmaceutica Sinica BPhytoecdysteroids (PE).ReviewPhytoecdysteroids (PEs) have a wide range of biological, pharmacological and medicinal properties involved in the prevention and treatment of acute and chronic diseases. PEs are effective against various types of cancer because of their anti-inflammatory and antioxidant mechanisms.No
The Acute Effects of a Multi-Ingredient Herbal Supplement on Performance Fatigability:
A Double-Blind, Randomized, and Placebo- Controlled Tri
Ryan et al.2021Journal of dietary supplementsRhaponticum carthamoides (RCE) and Rhodiola rosea (RRE)Applied researchInitial animal studies suggest that supplementation with RCE and RRE improves performance after short-term resistance training. However, the effect of these extracts on acute human performance remains uncertain. The study found that acute intake of the combined supplement did not affect performance fatigue or affective responses during or after repeated isokinetic strength tests.No
Acute and chronic effects of Rhaponticum carthamoides and Rhodiola rosea extracts supplementation coupled to resistance exercise on muscle protein synthesis and mechanical power in ratsRoumanille et al.2020Journal of the International Society of Sports Nutrition
Rhaponticum carthamoides and Rhodiola rosea Applied researchUpon acute administration and in combination with resistance training, Rha extract can increase muscle protein synthesis, and in combination with Rho, a synergistic effect can be expected. With chronic administration and resistance training, the same combination of Rha + Rho improves muscle strength and power performance without altering muscle mass and fiber cross-sectional area. Interestingly, a different ratio (Rha + Rho 70-30%) had a significant effect on muscle mass in the chronic study, suggesting that an optimal ratio of a given dose exists.No
Dietary PhytoecdysteroidsDinan et al.2020Handbook of Dietary PhytochemicalsPhytoecdysteroids ChapterEcdysteroids are becoming increasingly important in nutrition. Consumption may increase significantly in the future if: other crops are manipulated to increase the content of ecdysteroids, second, phytoecdysteroids become therapeutic agents, and third, phytoecdysteroid-containing supplements become more popular.No
Ecdysteroids as non‐conventional anabolic agent: performance enhancement by ecdysterone supplementation in humansIsenmann et al. 2019Archives of ToxicologyEcdysterone-containing supplementsApplied researchThis project demonstrates the performance-enhancing effects of ecdysterone in humans. In contrast, activation of the androgen receptor beta-activates the estrogen receptor, as shown in the literature.No
Rhaponticum carthamoides transformed root extract inhibits human glioma cells viability, induces double-strand DNA damage, H2A.X phosphorylation, and PARP1 cleavageSkała et al.2018CytotechnologyRhaponticum carthamoidesApplied researchIn conclusion, Rhaponticum carthamoides transformed root extract, which is rich in caffeoylquinic acid derivatives, may be a promising source for a new anti-cancer agent. Our findings confirm those of previous studies and indicate that the transformed root extract of Rhaponticum carthamoides can mediate apoptosis and death of glioma cells through multiple pathways.No
Rhaponticum carthamoides Transformed Root Extract Has Potent Anticancer Activity in Human Leukemia and Lung Adenocarcinoma Cell LinesSkała et al.2018Oxidative Medicine & Cellular LongevityRhaponticum carthamoides transformed root extract (Rc TR)Applied researchBoth current and previous findings show that transformed roots of R. carthamoides can inhibit cell viability and induce apoptosis in various types of cancer cells (such as glioma cells, leukemia cells or lung adenocarcinoma cells). In addition, the present study showed that the extract of Rc TR decreased mitochondrial membrane potential in all human cancer cell lines tested and possessed genotoxic activity.No
Phytoecdysteroids: A Novel, Non-Androgenic Alternative for Muscle Health and PerformanceZwetsloot et al. 2014Journal of Steroids & Hormonal SciencePhytoecdysteroids (PE).EditorialThere is an abundance of data on the anabolic effects of PEs in rodent models with limited adverse side effects. The nonandrogenic nature of PEs on tissues makes the investigation of PEs on skeletal muscle and their potential use for reducing sarcopenia, treating muscle regeneration after damage and improving athletic performance intriguing.No
Effects of rhaponticum carthamoides versus glycyrrhiza glabra and punica granatum extracts on metabolic syndrome signs in ratsDushkin et al.2014BMC complementary & alternative medicineRhaponticum carthamoides, Glycyrrhiza glabra and Punica granatum Applied researchThe extract of R. carthamoides roots showed complex beneficial activity, which was superior to that of the commercial ethanolic extracts of G. glabra roots and P. granatum plant. Therefore, R. carthamoides extract supports the evidence that natural ingredients of R. carthamoides are promising candidates for drug and nutritional ingredients to prevent or ameliorate the most common manifestation of lifestyle-related cluster diseases caused by a high-fat diet (HFD), such as diabetes and obesity.No
Estrogen receptor beta is involved in skeletal muscle hypertrophy induced by the phytoecdysteroid ecdysteroneParr et al.2014Molecular nutrition & food researchPhytoecdysteroid ecdysterone (Ecdy)Applied researchThe study results indicate that ERβ is involved in mediating the anabolic activity of Ecdy. These findings offer new therapeutic perspectives for the treatment of muscle injuries, sarcopenia and cachectic diseases, but also imply that such substance could be abused.No
Chemistry and pharmacology of Rhaponticum carthamoides: A reviewKokoska & Janovska 2009PhytochemistryRhaponticum carthamoidesReviewA large number of pharmacological and phytochemical studies conducted over the past 30 years have demonstrated the enormous medicinal potential of R. carthamoides. Different types of preparations and individual compounds derived from this species have been found to have different pharmacological effects on different organs such as the brain, blood, cardiovascular system and nervous system, as well as on different biochemical and physiological processes, functions including proteosynthesis, work capacity, reproduction and sexual function.No